Studies to quantify the population size of Masked Flowerpiercers have not yet been conducted, but it is common enough to be listed as stable (BirdLife International 2016). Masked Flowerpiercers have an estimated generation length of 3.7 years (BirdLife International 2016). Parker et al. (1996) categorize Masked Flowerpiercer as common relative to other Neotropical birds, with a center of abundance in the upper montane zone. No information is available on age at first breeding, survivorship, or population regulation.
A recent study on blood parasites in birds of the Ecuadorian Andes found the presence of Haemoproteus in a sampled Masked Flowerpiercer (Munro et al 2009). Oniki and Willis (1991) reported the presence of mites on D. cyanea in Colombia.