The nest of the Buff-throated Saltator is a bulky cup. The nest site usually is 0.3-2 m above the ground, in a bush or a tree, but may be as high as 9 m (Skutch 1954). In Costa Rica the clutch is two, but may be three in the Guianas (Penard and Penard 1910).
In Costa Rice the Buff-throated Saltator breeds from March-August (Skutch 1954). In central Panama, nests with eggs were reported from 1 April-19 July 19. Breeding in Suriname is from February-August (Haverschmidt 1968). Only the female incubates the eggs (Skutch 1954, Wetmore et al. 1984). The incubation period is 13-14 days, rarely to 16 days (Skutch 1954). In Costa Rica may raise two broods in one season (Skutch 1954). From the nests, an average measurement from 47 eggs was 27.5 x 19.2 mm. After hatching, the birds would stay in the nest for 13-15 days while both parents fed them (Skutch 1954).